CLIMATE
Seasonal and climate change effects on DNA methylation and their implications in the progression from amnestic mild cognitive impairment to Alzheimer's disease (AD)
The objective is to study the effects of climate change on DNA methylation and evaluate its impact on the progression of amnestic mild cognitive impairment (aMCI) in patients with positive Alzheimer’s disease biomarker profiles.
Center: Fundació Mútua Terrassa per a la Docència i Recerca Biomèdica i Social F.P.C.
Climate change poses a risk to public health. Rising temperatures negatively affect many chronic diseases, including Alzheimer’s disease (AD), which is worsened by extreme weather conditions. This project analyzes how DNA methylation, modulated by environmental factors, may influence the course of AD. A total of 96 patients in the prodromal phase with amnestic mild cognitive impairment will be included, and omics techniques will be used to study DNA methylation in two extreme scenarios: heatwaves and cold winters. A pilot study will also be conducted on the effects of intensive cognitive stimulation during critical heat periods. The project will develop a technological tool to mitigate the effects of climate change on vulnerable patients and provide data to support adaptive strategies and climate comfort initiatives in Barcelona.
